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It is located in the outer surface of plasma membranes of epithelial cells and cleaves the extracellular GSH to glutamate and cysteinyl-glycine, which is subsequently hydrolyzed by a dipeptidase to yield the constituent amino acids[37]

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It has been postulated that the increase in allergic diseases may be due to bacterial dysbiosis and reduced biodiversity of the healthy microbiota [1, 2, 39]

40,84 Additionally, by increasing lipid storage in adipose tissue, insulin indirectly induces leptin release from adipocytes, which strongly mediates satiety by acting on hypothalamic brain cells expressing the leptin receptor